Resistin becomes less futile

Introduction: When More Becomes Less

When becomes more in fact less?

The principles ‘in dubio abstine’ and ‘primum non nocere’ are as least as old as the language they are written in, and have been made very concrete in criticisms on iatrogenesis, medicalization, polypharmacy and polypragmasy. Clinical decision analysis [1], health technology assessment, and critical appraisal of clinical evidence [2] have provided useful methods to translate these principles in...

Universal Protocol becomes less prescriptive in its 2010 version.

Memory for context becomes less specific with time.

Context memories initially require the hippocampus, but over time become independent of this structure. This shift reflects a consolidation process whereby memories are gradually stored in distributed regions of the cortex. The function of this process is thought to be the extraction of statistical regularities and general knowledge from specific experiences. The current study examined this ide...

When ‘more for less’ becomes ‘less for less’: the implications of central decision-making for the delivery of frontline services

With his unique perspective on the public sector, the Comptroller and Auditor General, Sir Amyas Morse, explains some of the elements of financial management and planning that determine success in major reform programmes. He uses examples from local government, adult social care, and NHS reforms to conclude that, too often, ‘efficiency’ improvements have shaded over into unplanned grass roots s...